The synthesis of four new dissymmetric cavitands is reported. These deep-walled receptors are constructed from a resorcin[4]arene scaffold bearing anti-disposed quinoxaline substituents, with either N-haloalkyl-diazaphthalimide (1), dinitrophenyl (2) or diaminophenyl (3) moieties as the other wall components. The structure and inclusion properties of 1 and 2 have been probed in solution by NMR spectroscopy and notably in the solid-state by X-ray crystallography. The diazaphthalimide-based compounds 1 crystallise as 1:1 host-guest complexes with chloroform, with the resorcin[4]arene scaffolds adopting pinched cone conformations. Conversely, the dinitrophenyl-variant 2 features a more open, symmetric structure in the solid-state and co-crystallises with two acetone molecules within the central cavity. Preliminary binding experiments in mesitylene-d₁₂ at 303 K demonstrate 1 (K_app = 5 × 10² M⁻¹) and 2 (K_app = 2 × 10² M⁻¹) are effective hosts for cyclohexane guest molecules in the absence of competitive solvent inclusion.

据报道，合成了四个新的不对称空泡体。这些深壁受体由带有抗位错喹喔啉取代基的间苯二酚[4]芳烃骨架构成，N-卤代烷基-二氮杂苯二甲酰亚胺（1），二硝基苯基（2）或二氨基苯基（3）部分为其他壁成分。1和2的结构和内含物性质已通过NMR光谱在溶液中进行了探测，特别是通过X射线晶体学在固态中进行了探测。二氮杂苯二甲酰亚胺基化合物1与氯仿结晶为1：1主宾复合物，间苯二酚[4]芳烃骨架采用捏合的圆锥构象。相反，二硝基苯基变体2在固态时具有更开放的对称结构，并与中心腔内的两个丙酮分子共结晶。 在303 K的均三甲苯基d ₁₂中的初步结合实验证明1（K _app  = 5×10 ²  M ^-1）和2（K _app  = 2×10 ²  M ^-1）是环己烷客体分子的有效主体。竞争性溶剂包合。