当前位置：
X-MOL 学术
›
ACS Appl. Mater. Interfaces
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Fabrication of an Anti-Biofouling Plasma-Filtration Membrane by an Electrospinning Process Using Photo-Cross-linkable Zwitterionic Phospholipid Polymers
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-05-23 00:00:00 , DOI: 10.1021/acsami.7b03308 Jiae Seo 1 , Ji-Hun Seo 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-05-23 00:00:00 , DOI: 10.1021/acsami.7b03308 Jiae Seo 1 , Ji-Hun Seo 1
Affiliation
|
The goal of this study is to fabricate a stable plasma filtration membrane with antibiofouling properties via an electrospinning process. To this end, a random-type copolymer consisting of zwitterionic phosphorylcholine (PC) groups and ultraviolet (UV)-cross-linkable phenyl azide groups was synthesized. The zwitterionic PC group provides antibiofouling properties, and the phenyl azide group enables the stable maintenance of the fibrous nanostructure of hydrophilic zwitterion polymers in aqueous medium via a simple UV curing process. To demonstrate the antibiofouling nature of the PC group, a polymer without antibiofouling PC groups was also prepared for comparison. The successful synthesis of the random-type copolymers containing phenyl azide groups was proven by H1 nuclear magnetic resonance and Fourier transform infrared spectroscopy, and the fibrous structure of the prepared membranes was observed by field emission scanning electron microscopy. The antibiofouling properties were analyzed by fluorescein isothiocyanate-labeled bovine serum albumin adsorption and platelet adhesion tests. The experimental results show that membranes containing zwitterionic PC groups exhibited obvious decreases in platelet adhesion and protein adsorption. Platelet-rich plasma solution was filtered using the prepared membranes to test their filtration properties. The sequential filtration process removed 80% and almost 98% of the platelets. This finding confirmed that the membrane retained its blood-inert biomaterial surface in a complex medium that included blood plasma and platelets.
中文翻译：
通过使用光交联的两性离子磷脂聚合物的静电纺丝工艺制备抗生物结垢的血浆过滤膜
这项研究的目的是通过静电纺丝工艺制造出具有抗生物污垢特性的稳定的血浆过滤膜。为此，合成了由两性离子磷酸胆碱（PC）基团和紫外线（UV）可交联的苯基叠氮化物基团组成的无规共聚物。两性离子PC基团具有抗污垢性能，而叠氮苯基基团可通过简单的UV固化过程稳定地维持水性介质中亲水性两性离子聚合物的纤维纳米结构。为了证明PC基团的抗生物结垢性质，还制备了没有抗生物结垢的PC基团的聚合物用于比较。H 1证明了成功合成含叠氮苯基的无规共聚物核磁共振和傅立叶变换红外光谱，并通过场发射扫描电子显微镜观察了所制备膜的纤维结构。通过异硫氰酸荧光素标记的牛血清白蛋白吸附和血小板粘附试验分析了抗污垢性能。实验结果表明，含两性离子PC基团的膜在血小板粘附和蛋白质吸附方面表现出明显的下降。使用制备的膜过滤富含血小板的血浆溶液，以测试其过滤性能。顺序过滤过程去除了80％和几乎98％的血小板。这一发现证实了该膜将其血液惰性生物材料表面保留在包括血浆和血小板在内的复杂介质中。
更新日期：2017-06-02
中文翻译：
通过使用光交联的两性离子磷脂聚合物的静电纺丝工艺制备抗生物结垢的血浆过滤膜
这项研究的目的是通过静电纺丝工艺制造出具有抗生物污垢特性的稳定的血浆过滤膜。为此，合成了由两性离子磷酸胆碱（PC）基团和紫外线（UV）可交联的苯基叠氮化物基团组成的无规共聚物。两性离子PC基团具有抗污垢性能，而叠氮苯基基团可通过简单的UV固化过程稳定地维持水性介质中亲水性两性离子聚合物的纤维纳米结构。为了证明PC基团的抗生物结垢性质，还制备了没有抗生物结垢的PC基团的聚合物用于比较。H 1证明了成功合成含叠氮苯基的无规共聚物核磁共振和傅立叶变换红外光谱，并通过场发射扫描电子显微镜观察了所制备膜的纤维结构。通过异硫氰酸荧光素标记的牛血清白蛋白吸附和血小板粘附试验分析了抗污垢性能。实验结果表明，含两性离子PC基团的膜在血小板粘附和蛋白质吸附方面表现出明显的下降。使用制备的膜过滤富含血小板的血浆溶液，以测试其过滤性能。顺序过滤过程去除了80％和几乎98％的血小板。这一发现证实了该膜将其血液惰性生物材料表面保留在包括血浆和血小板在内的复杂介质中。
京公网安备 11010802027423号