由苯硼酸-邻苯二酚络合形成的pH，葡萄糖和多巴胺三重响应，可自愈的粘合水凝胶,Polymer Chemistry

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由苯硼酸-邻苯二酚络合形成的pH，葡萄糖和多巴胺三重响应，可自愈的粘合水凝胶
Polymer Chemistry ( IF 4.1 ) Pub Date : 2017-04-13 00:00:00 , DOI: 10.1039/c7py00519a
Meng Shan _{1,

2,

3,

4,

5} , Chu Gong _{1,

2,

3,

4,

5} , Bingqiang Li _{1,

2,

3,

4,

5} , Guolin Wu _{1,

2,

3,

4,

5}

Affiliation

通过以下方法成功制备了可注射的聚乙二醇（PEG）水凝胶使用多巴胺官能化的4臂PEG（4臂-PEG-DA）和苯硼酸修饰的4臂PEG（4臂-PEG-PBA）进行硼酸盐-邻苯二酚络合。通过在pH 9.0下将15 wt％的4臂PEG-DA与15 wt％的4臂PEG-PBA缓冲溶液混合，可在10 s内形成水凝胶。通过傅立叶变换红外（FT-IR）光谱，流变学测量，扫描电子显微镜（SEM）和搭接剪切强度测试对水凝胶进行了表征。此外，降解实验和药物释放试验证明了基于苯硼酸-邻苯二酚络合的水凝胶的pH，葡萄糖和多巴胺反应性。搭接剪切强度测试表明，水凝胶具有自我修复的能力，这是苯硼酸-邻苯二酚动态共价键赋予的。而且，体外细胞毒性试验证明了水凝胶具有出色的细胞相容性。所有实验的结果表明，我们新开发的多功能水凝胶可在生物医学领域（如药物输送，组织工程和生物粘合剂）中具有潜在的应用。

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A pH, glucose, and dopamine triple-responsive, self-healable adhesive hydrogel formed by phenylborate–catechol complexation

An injectable polyethylene glycol (PEG) hydrogel was successfully prepared via borate–catechol complexation using dopamine functionalized 4-armed PEG (4-arm-PEG-DA) and phenylboronic acid modified 4-armed PEG (4-arm-PEG-PBA). The hydrogel was formed within 10 s by mixing 15 wt% 4-arm-PEG-DA with 15 wt% 4-arm-PEG-PBA buffer solutions at pH 9.0. The hydrogel was characterized by Fourier transform infrared (FT-IR) spectroscopy, rheological measurements, scanning electron microscopy (SEM) and lap shear strength tests. Furthermore, pH, glucose and dopamine responsiveness of the hydrogel based on phenylborate–catechol complexation was demonstrated by degradation experiments and drug release tests. The lap shear strength tests indicated that the hydrogel possessed the ability of self-healing which was bestowed by the phenylborate–catechol dynamic covalent bond. Moreover, the hydrogel could serve as a decent bio-adhesive due to its adhesion properties on different substrates especially the porcine skin. In vitro cytotoxicity tests demonstrated the excellent cytocompatibility of the hydrogel. The results of all the experiments indicate that our newly developed multi-functionalized hydrogel can have potential applications in biomedical fields such as drug delivery, tissue engineering, and bio-adhesives.

更新日期：2017-05-31

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