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Synthesis and biological evaluation of 1-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)pyridinium hydroxide inner salt derivatives.
Journal of Pharmaceutical Sciences ( IF 3.197 ) Pub Date : 1976 Apr
Grier, N, Strelitz, R A

Eight 1-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)pyridinium hydroxide inner salts were synthesized, and the antibacterial, antifungal, anticoccidial, and anthelmintic activities were determined against different microorganisms, the protozoan Eimeria tenella, and trichostrongyle nematodes. All were noninhibitory to Gram-negative bacteria and the parasites. The pyridine, 4-benzylpyridine, and 2-isoquinoline inner salt derivatives controlled only Rhizoctonia solani of the four genera of fungi challenged.

中文翻译:

1-(4-羟基-2-氧代-2H-1-苯并吡喃-3-基)氢氧化吡啶鎓内盐衍生物的合成及生物学评价。

合成了八种1-(4-羟基-2-氧代-2H-1-苯并吡喃-3-基)吡啶鎓内盐,并确定了对不同微生物原生动物艾美球虫的抗菌,抗真菌,抗球虫和驱虫活性。和线虫的线虫。全部对革兰氏阴性菌和寄生虫均无抑制作用。吡啶,4-苄基吡啶和2-异喹啉内盐衍生物仅控制所挑战真菌的四个属中的茄状立枯丝核菌。
更新日期:2017-01-31
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