EHD2 restrains dynamics of caveolae by an ATP-dependent, membrane-bound, open conformation [Biochemistry],Proceedings of the National Academy of Sciences of the United States of America

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EHD2 restrains dynamics of caveolae by an ATP-dependent, membrane-bound, open conformation [Biochemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2017-05-30 09:39:12 , DOI: 10.1073/pnas.1614066114
Maria Hoernke _{1,

2,

3} , Jagan Mohan ₄ , Elin Larsson ₅ , Jeanette Blomberg ₅ , Dana Kahra ₅ , Sebastian Westenhoff ₁ , Christian Schwieger ₆ , Richard Lundmark _{4,

5}

Affiliation

The EH-domain–containing protein 2 (EHD2) is a dynamin-related ATPase that confines caveolae to the cell surface by restricting the scission and subsequent endocytosis of these membrane pits. For this, EHD2 is thought to first bind to the membrane, then to oligomerize, and finally to detach, in a stringently regulated mechanistic...

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