Deconvoluting the Bioactivity of Calcium Phosphate‐Based Bone Graft Substitutes: Strategies to Understand the Role of Individual Material Properties,Advanced Healthcare Materials

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Deconvoluting the Bioactivity of Calcium Phosphate‐Based Bone Graft Substitutes: Strategies to Understand the Role of Individual Material Properties
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-05-23 , DOI: 10.1002/adhm.201601478
Víctor Pablo Galván-Chacón ₁ , Pamela Habibovic ₁

Affiliation

Calcium phosphate (CaP)‐based ceramics are the most widely applied synthetic biomaterials for repair and regeneration of damaged and diseased bone. CaP bioactivity is regulated by a set of largely intertwined physico‐chemical and structural properties, such as the surface microstructure, surface energy, porosity, chemical composition, crystallinity and stiffness. Unravelling the role of each individual property in the interaction between the biomaterial and the biological system is a prerequisite for evolving from a trial‐and‐error approach to a design‐driven approach in the development of new functional biomaterials. This progress report critically reviews various strategies developed to decouple the roles of the individual material properties in the biological performance of CaP ceramics. It furthermore emphasizes on the importance of a comprehensive and adequate material characterization that is needed to enhance our knowledge of the property‐function relationship of biomaterials used in bone regeneration, and in regenerative medicine in general.

中文翻译：

对基于磷酸钙的骨移植替代物的生物活性进行反卷积：理解个体材料特性作用的策略

磷酸钙（CaP）基陶瓷是修复和再生受损和患病骨骼的最广泛应用的合成生物材料。CaP的生物活性受到一系列相互交织的物理化学和结构特性的调控，例如表面微观结构，表面能，孔隙率，化学成分，结晶度和刚度。在新功能生物材料的开发中，从试错法发展到设计驱动法的先决条件，是要弄清每个属性在生物材料与生物系统之间的相互作用中的作用。该进展报告严格地审查了开发的各种策略，这些策略可以使单个材料特性在CaP陶瓷的生物学性能中的作用脱钩。

更新日期：2017-05-23

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