Discovery of N-(Naphthalen-1-yl)-N′-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers,Organic Letters

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Discovery of N-(Naphthalen-1-yl)-N′-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers
Organic Letters ( IF 4.9 ) Pub Date : 2017-05-22 00:00:00 , DOI: 10.1021/acs.orglett.7b00901
Jie Gao ₁ , Subhajit Bhunia ₂ , Kailiang Wang ₁ , Lu Gan ₁ , Shanghua Xia ₁ , Dawei Ma _{1,

2}

Affiliation

A class of N-(naphthalen-1-yl)-N′-alkyl oxalamides have been proven to be powerful ligands, making a coupling reaction of (hetero)aryl iodides with primary amines proceed at 50 °C with only 0.01 mol % of Cu₂O and ligand as well as a coupling reaction of (hetero)aryl bromides with primary amines and ammonia at 80 °C with only 0.1 mol % of Cu₂O and ligand. A wide range of coupling partners work well under these conditions, thereby providing an easy to operate method for preparing (hetero)aryl amines.

中文翻译：

的发现ñ - （萘-1-基） - ñ ' -烷基草酰胺配体的Cu启用催化芳基胺化高失误

一类N-（萘-1-基）-N'-烷基草酰胺已被证明是强力的配体，使得（杂）芳基碘化物与伯胺的偶联反应在50°C时仅进行0.01 mol％ Cu ₂ O和配体，以及（杂）芳基溴化物与伯胺和氨在80°C下仅含0.1 mol％的Cu ₂ O和配体的偶联反应。各种各样的偶合伴侣在这些条件下都能很好地工作，从而提供了一种易于操作的制备（杂）芳基胺的方法。

更新日期：2017-05-22

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