Abstract

A one-pot three-component route for the synthesis of rhodanine derivatives by the reaction of primary amines, carbon disulfide, and maleic anhydride in water is described. The reactions proceed via a sequential Michael addition–intramolecular amide bond formation. Bis(rhodanine) derivatives were also synthesized by using a diamine in this protocol.

A one-pot three-component route for the synthesis of rhodanine derivatives by the reaction of primary amines, carbon disulfide, and maleic anhydride in water is described. The reactions proceed via a sequential Michael addition–intramolecular amide bond formation. Bis(rhodanine) derivatives were also synthesized by using a diamine in this protocol.

中文翻译：

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一锅三成分法合成水中若丹宁衍生物

摘要

描述了通过伯胺，二硫化碳和马来酸酐在水中反应合成罗丹宁衍生物的一锅三组分途径。反应通过依次的迈克尔加成-分子内酰胺键形成进行。在该方案中还通过使用二胺合成了双（罗丹宁）衍生物。

描述了通过伯胺，二硫化碳和马来酸酐在水中反应合成罗丹宁衍生物的一锅三组分途径。反应通过依次的迈克尔加成-分子内酰胺键形成进行。在该方案中还通过使用二胺合成了双（罗丹宁）衍生物。