Fluorescence is widely used for cell imaging due to its high sensitivity and rich color choice but limited for in vivo imaging because of its low light penetration. Meanwhile, magnetic resonance imaging (MRI) is widely applied for in vivo diagnosis but not suitable for cell imaging because of its low resolution. Compared to ¹H-MRI, ¹⁹F-MRI is more suitable for clinical application due to its high sensitivity but fabricating ¹⁹F-MRI probes is a great challenge. Therefore, it is highly desirable to develop a dual-modal imaging probe for both cell fluorescence imaging and in vivo ¹⁹F-MRI with high sensitivity and deep penetration. In this study, ¹⁹F moiety loaded nanocomposites with an organic fluorescent core were successfully prepared via a facile strategy by encapsulating organic dyes with oleylamine-functionalized polysuccinimide and 1H,1H,2H,2H-perfluorodecyltriethoxysilane (PDTES). The aggregation of organic fluorescent dyes in the core results in significant fluorescence for optical imaging, while the ¹⁹F moieties on PDTES allow for simultaneous ¹⁹F MRI. Moreover, the nanocomposites exhibited high water dispersibility and excellent biocompatibility. These properties make them promising for both cell imaging and in vivo imaging applications.

中文翻译：

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用于荧光和¹⁹ F磁共振成像的多功能纳米探针

荧光由于其高灵敏度和丰富的色彩选择而被广泛用于细胞成像，但由于其低的光穿透性而在体内成像中受到限制。同时，磁共振成像（MRI）由于其低分辨率而被广泛用于体内诊断，但不适用于细胞成像。与¹ H-MRI相比，¹⁹ F-MRI具有高灵敏度，因此更适合临床应用，但是制造¹⁹ F-MRI探头是一个巨大的挑战。因此，非常需要开发一种具有高灵敏度和深度穿透性的用于细胞荧光成像和体内 ¹⁹ F-MRI的双峰成像探针。在这项研究中，¹⁹通过使用油胺胺官能化的聚琥珀酰亚胺和1 H，1 H，2 H，2 H-全氟癸基三乙氧基硅烷（PDTES）封装有机染料，通过简便的策略成功制备了具有有机荧光核的F部分负载的纳米复合材料。核心中有机荧光染料的聚集导致光学成像产生显着的荧光，而PDTES上的¹⁹ F部分允许同时进行¹⁹ F MRI。此外，纳米复合材料表现出高的水分散性和优异的生物相容性。这些特性使它们对于细胞成像和体内成像应用都有希望。