合成和二醇为基础的不饱和聚酯的表征：聚（二醇富马酸酯）和聚（二醇延胡索酸酯<i>共</i>-琥珀酸酯）,Biomacromolecules

当前位置： X-MOL 学术 › Biomacromolecules › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

合成和二醇为基础的不饱和聚酯的表征：聚（二醇富马酸酯）和聚（二醇延胡索酸酯共-琥珀酸酯）
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-05-09 00:00:00 , DOI: 10.1021/acs.biomac.7b00044
Alexander M. Tatara ₁ , Emma Watson ₁ , Tejus Satish , David W. Scott , Dimitrios P. Kontoyiannis ₂ , Paul S. Engel , Antonios G. Mikos

Affiliation

在这项工作中，我们描述了聚（二醇富马酸酯）和聚的变体的合成和表征（二醇延胡索酸酯共-琥珀酸酯）。通过费歇尔酯化反应，α，ω-二醇和二羧酸聚合形成脂肪族聚酯共聚体。由于富马酸的碳-碳双键，将其掺入大分子单体主链结构会导致不饱和链。通过选择不同长度的α，ω-二醇（1,6-己二醇，1,8-辛二醇和1,10-癸二醇）并控制二羧酸单体进料中的富马酸含量（33、50和100）摩尔％），合成了九个基于二醇的大分子单体变体，并表征了分子量，每链不饱和键的数量和热性质。还在大分子单体的子集中测量了降解和体外细胞毒性。作为原理证明，将大分子单体网络进行光交联以证明使用不饱和大分子单体骨架进行自由基加成的能力。还基于二醇的长度和不饱和键的数量，对交联的大分子单体网络的理化性质（溶胀，溶胶分数，压缩模量）进行了表征。使用从这些基于二醇的大分子单体和大分子单体网络生成的数据构建统计模型，以评估单体输入对最终大分子单体和大分子单体网络特性的影响。具有可通过自由基加成改性的能力，可生物降解的不饱和聚酯在诸如药物递送载体和组织支架的装置的设计中用作重要的大分子单体。鉴于能够根据单体输入参数广泛控制最终的大分子单体性能，共琥珀酸酯）代表了令人兴奋的一类新的大分子单体。

"点击查看英文标题和摘要"

Synthesis and Characterization of Diol-Based Unsaturated Polyesters: Poly(diol fumarate) and Poly(diol fumarate-co-succinate)

In this work, we describe the synthesis and characterization of variants of poly(diol fumarate) and poly(diol fumarate-co-succinate). Through a Fischer esterification, α,ω-diols and dicarboxylic acids were polymerized to form aliphatic polyester comacromers. Because of the carbon-carbon double bond of fumaric acid, incorporating it into the macromer backbone structure resulted in unsaturated chains. By choosing α,ω-diols of different lengths (1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) and controlling the amount of fumaric acid in the dicarboxylic acid monomer feed (33, 50, and 100 mol %), nine diol-based macromer variants were synthesized and characterized for molecular weight, number of unsaturated bonds per chain, and thermal properties. Degradation and in vitro cytotoxicity were also measured in a subset of macromers. As proof-of-principle, macromer networks were photo-cross-linked to demonstrate the ability to perform free radical addition using the unsaturated macromer backbone. Cross-linked macromer networks were also characterized for physicochemical properties (swelling, sol fraction, compressive modulus) based on diol length and amount of unsaturated bonds. A statistical model was built using data generated from these diol-based macromers and macromer networks to evaluate the impact of monomer inputs on final macromer and macromer network properties. With the ability to be modified by free radical addition, biodegradable unsaturated polyesters serve as important macromers in the design of devices such as drug delivery vehicles and tissue scaffolds. Given the ability to extensively control final macromer properties based on monomer input parameters, poly(diol fumarate) and poly(diol fumarate-co-succinate) represent an exciting new class of macromers.

更新日期：2017-05-18

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南