Synthesis of Brominated Thiazoles via Sequential Bromination–Debromination Methods,The Journal of Organic Chemistry

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Synthesis of Brominated Thiazoles via Sequential Bromination–Debromination Methods
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2017-05-16 00:00:00 , DOI: 10.1021/acs.joc.7b00495
Eric J. Uzelac ₁ , Seth C. Rasmussen ₁

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The synthesis of the full family of bromothiazoles has been revisited in order to update and optimize their production. The species reported include 2-bromothiazole, 4-bromothiazole, 5-bromothiazole, 2,4-dibromothiazole, 2,5-dibromothiazole, 4,5-dibromothiazole, and 2,4,5-tribromothiazole, the majority of which are produced via sequential bromination and debromination steps. This complete family can now be produced without the use of elemental bromine, and the presented methods have allowed the physical and NMR spectroscopic characterization of the full family to be reported for the first time.

中文翻译：

顺序溴化-脱溴方法合成溴化噻唑

溴噻唑全家族的合成已被重新研究，以更新和优化其生产。报告的物种包括2-溴噻唑，4-溴噻唑，5-溴噻唑，2,4-二溴噻唑，2,5-二溴噻唑，4,5-二溴噻唑和2,4,5-三溴噻唑，其中大多数是通过依次进行溴化和脱溴步骤。现在可以在不使用元素溴的情况下生产该完整家族，并且所提出的方法已允许首次报道该完整家族的物理和NMR光谱表征。

更新日期：2017-05-16

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