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Enhancing Mechanical Properties of Silk Fibroin Hydrogel through Restricting the Growth of β-Sheet Domains
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-05-04 00:00:00 , DOI: 10.1021/acsami.7b04623 Dihan Su 1 , Meng Yao 1 , Jie Liu 1 , Yiming Zhong 2 , Xin Chen 1 , Zhengzhong Shao 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-05-04 00:00:00 , DOI: 10.1021/acsami.7b04623 Dihan Su 1 , Meng Yao 1 , Jie Liu 1 , Yiming Zhong 2 , Xin Chen 1 , Zhengzhong Shao 1
Affiliation
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Usually, regenerated silk fibroin (RSF) hydrogels cross-linked by chemical agents such as horseradish peroxide (HRP)/H2O2 perform elastic properties, while display unsatisfactory strength for practical applications especially as load-bearing materials, and inadequate stability when incubated in a simulated in vivo environment. Here, the RSF hydrogel with both excellent strength and elasticity was prepared by inducing the conformation transition from random coil to β-sheet in a restricted RSF network precross-linked by HRP/H2O2. Such “dual-networked” hydrogels, regarding the one with 10 wt % RSF (Mw: 220 kDa) as a representative, show around 100% elongation, as well as the compressive modulus and tensile modulus up to 3.0 and 2.5 MPa respectively, which are much higher than those of physically cross-linked natural polymer hydrogels (commonly within 0.01–0.1 MPa at the similar solid content). It has been shown that the enhanced comprehensive mechanical properties of RSF hydrogels derive from the formation of small-sized and uniformly distributed β-sheet domains in the hydrogel during the conformation transition of RSF whose size is limited by the first network formed by cross-linkers with HRP/H2O2. Importantly, the tough RSF hydrogel changes the normally weak recognition of various RSF hydrogels and holds a great potential to be the material in biomedical field because it seems to be very promising regarding its biocompatibility, biodegradability, etc.
中文翻译：
通过限制β-Sheet域的生长来增强丝素蛋白水凝胶的机械性能
通常，通过化学试剂（例如辣根过氧化物（HRP）/ H 2 O 2）交联的再生丝素蛋白（RSF）水凝胶具有弹性，同时在实际应用中（尤其是作为承重材料）显示出不令人满意的强度，并且在孵育时稳定性不足在模拟的体内环境中。在此，通过在由HRP / H 2 O 2预交联的限制性RSF网络中诱导从无规卷曲到β-折叠的构象转变，制备了具有优异强度和弹性的RSF水凝胶。。这样的“双网状”水凝胶，以10％的RSF（Mw：220 kDa）为代表，显示出约100％的伸长率，以及分别高达3.0和2.5 MPa的压缩模量和拉伸模量，远远高于物理交联的天然聚合物水凝胶（在相似的固体含量下，通常在0.01-0.1 MPa范围内）。研究表明，RSF水凝胶增强的综合机械性能源自在RSF构象转变过程中在水凝胶中形成小且均匀分布的β-sheet结构域，其大小受到交联剂形成的第一个网络的限制带HRP / H 2 O 2。重要的是，坚韧的RSF水凝胶改变了通常对各种RSF水凝胶的较弱认识，并具有成为生物医学领域材料的巨大潜力，因为就其生物相容性，生物降解性等方面而言，这似乎是非常有前途的。
更新日期：2017-05-12
中文翻译：
通过限制β-Sheet域的生长来增强丝素蛋白水凝胶的机械性能
通常，通过化学试剂（例如辣根过氧化物（HRP）/ H 2 O 2）交联的再生丝素蛋白（RSF）水凝胶具有弹性，同时在实际应用中（尤其是作为承重材料）显示出不令人满意的强度，并且在孵育时稳定性不足在模拟的体内环境中。在此，通过在由HRP / H 2 O 2预交联的限制性RSF网络中诱导从无规卷曲到β-折叠的构象转变，制备了具有优异强度和弹性的RSF水凝胶。。这样的“双网状”水凝胶，以10％的RSF（Mw：220 kDa）为代表，显示出约100％的伸长率，以及分别高达3.0和2.5 MPa的压缩模量和拉伸模量，远远高于物理交联的天然聚合物水凝胶（在相似的固体含量下，通常在0.01-0.1 MPa范围内）。研究表明，RSF水凝胶增强的综合机械性能源自在RSF构象转变过程中在水凝胶中形成小且均匀分布的β-sheet结构域，其大小受到交联剂形成的第一个网络的限制带HRP / H 2 O 2。重要的是，坚韧的RSF水凝胶改变了通常对各种RSF水凝胶的较弱认识，并具有成为生物医学领域材料的巨大潜力，因为就其生物相容性，生物降解性等方面而言，这似乎是非常有前途的。
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