Phosphoryl choline derivatives are important compounds for drug development. Also other phosphoesters have received increased demand in recent years. Many of such compounds rely 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP) as an intermediate. COP is available in a two-step reaction from the cyclic adduct of phosphorus chloride and ethylene glycol after oxidation. Although commercially available, in-house synthesis of COP is often required due to pricing, purity, and delivery issues. Air is a convenient and economical oxidizing agent, yet not used for synthesis of COP. While slow consumption of the P(III)-precursor 2-chloro-1,3,2-dioxaphospholane with molecular oxygen from a gas bottle, high amounts of unreacted oxygen are lavished and even may cause an explosion. Oxygen from air is a reasonable and safer alternative. Additionally, catalytic amounts of cobalt(II)chloride increase the reaction kinetics remarkably. The results presented allow a controlled and fast access to a variety of phosphoesters by optimized reaction conditions of COP and its derivatives.

磷酸胆碱衍生物是药物开发的重要化合物。近年来，其他磷酸酯也收到了增加的需求。许多这样的化合物依靠2-氯-2-氧代-1,3,2-二氧杂膦烷（COP）作为中间体。氧化后，氯化磷与乙二醇的环状加合物可通过两步反应制得COP。尽管有市售产品，但由于价格，纯度和交货问题，通常需要内部合成COP。空气是一种方便且经济的氧化剂，但尚未用于合成COP。虽然从气瓶中缓慢消耗掉P（III）前体2-氯-1,3,2-二氧杂磷杂环戊烷与分子氧，但大量未反应的氧却被大量消耗，甚至可能引起爆炸。空气中的氧气是一种合理且更安全的替代方法。此外，催化量的氯化钴（II）显着提高了反应动力学。所呈现的结果允许通过COP及其衍生物的优化反应条件来控制并快速获得各种磷酸酯。