An asymmetric doubly vinylogous Michael addition (DVMA) of α,β‐unsaturated γ‐butyrolactams to sterically congested β‐substituted cyclic dienones with high site‐, diastereo‐, and enantioselectivity has been achieved. An unprecedented DVMA/vinylogous Michael addition/isomerization cascade reaction affords chiral fused tricyclic γ‐lactams with four newly formed stereocenters.

中文翻译：

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α，β-不饱和γ-丁内酰胺对二烯酮的直接催化不对称双长乙烯基迈克尔加成反应

已实现了对位，非对映和对映异构体选择性高的α，β-不饱和γ-丁内酰胺向空间拥挤的β-取代的环状二烯的不对称双乙烯基迈克尔加成反应（DVMA）。前所未有的DVMA / vinyllogous Michael加成/异构化级联反应提供了具有四个新形成的立体中心的手性稠合三环γ-内酰胺。