Gram-Scale Synthesis of Hydrophilic PEI-Coated AgInS2 Quantum Dots and Its Application in Hydrogen Peroxide/Glucose Detection and Cell Imaging,Inorganic Chemistry

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Gram-Scale Synthesis of Hydrophilic PEI-Coated AgInS2 Quantum Dots and Its Application in Hydrogen Peroxide/Glucose Detection and Cell Imaging
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2017-05-05 00:00:00 , DOI: 10.1021/acs.inorgchem.7b00053
Lan Wang _{1,

2} , Xiaojiao Kang ₁ , Daocheng Pan ₁

Affiliation

Assisted with polyethylenimine, 4.0 L of water-soluble AgInS₂ quantum dots (AIS QDs) were successfully synthesized in an electric pressure cooker. As-prepared QDs exhibit yellow emission with a photoluminescence (PL) quantum yield up to 32%. The QDs also show excellent water/buffer stability. The highly luminescent AIS QDs are used to explore their dual-functional behavior: detection of hydrogen peroxide (H₂O₂)/glucose and cell imaging. The amino-functionalized AIS QDs show high sensitivity and specificity for H₂O₂ and glucose with detection limits of 0.42 and 0.90 μM, respectively. A linear correlation was established between PL intensity and concentration of H₂O₂ in the ranges of 0.5–10 μM and 10–300 μM, while the linear ranges were 1–10 μM and 10–1000 μM for detection of glucose. The AIS QDs reveal negligible cytotoxicity on HeLa cells. Furthermore, the luminescence of AIS QDs gives the function of optical imaging.

中文翻译：

亲水性PEI包覆的AgInS ₂量子点的克级合成及其在过氧化氢/葡萄糖检测和细胞成像中的应用

借助聚乙烯亚胺，在电压力锅中成功合成了4.0 L水溶性AgInS ₂量子点（AIS QD）。制备好的量子点显示黄色发射，光致发光（PL）量子产率高达32％。QD还显示出出色的水/缓冲液稳定性。高发光AIS QD用于探索其双重功能：过氧化氢（H ₂ O ₂）/葡萄糖的检测和细胞成像。氨基官能化的AIS QD对H ₂ O ₂和葡萄糖显示出高灵敏度和特异性，检测限分别为0.42和0.90μM。在PL强度和H ₂ O ₂浓度之间建立了线性关系用于检测葡萄糖的线性范围分别为0.5–10μM和10–300μM，而线性范围为1–10μM和10–1000μM。AIS QDs显示对HeLa细胞的细胞毒性微不足道。此外，AIS QD的发光具有光学成像功能。

更新日期：2017-05-05

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