Copper(ii)-mediated formation of oxazole-4-carbonitrile from acetophenone and coordinated cyanide anion via a radical coupling†,RSC Advances

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Copper(ii)-mediated formation of oxazole-4-carbonitrile from acetophenone and coordinated cyanide anion via a radical coupling†
RSC Advances ( IF 3.9 ) Pub Date : 2017-05-05 00:00:00 , DOI: 10.1039/c7ra01983a
Congjun Xu _{1,

2,

3,

4,

5} , Mingze Qin _{1,

2,

3,

4,

5} , Jun Yi _{1,

2,

3,

4,

5} , Yanjing Wang _{1,

2,

3,

4,

5} , Yanfeng Chen _{1,

2,

3,

4,

5} , Bingfu Zhang _{1,

2,

3,

4,

5} , Yanfang Zhao _{1,

2,

3,

4,

5} , Ping Gong _{1,

2,

3,

4,

5}

Affiliation

A protocol for the direct synthesis of 5-aryloxazole-4-carbonitrile from acetophenone was first described with potassium ferricyanide as a cheap and low toxicity cyanide reagent, in which, multiple bond formation was implemented via an oxygen mediated radical mechanism. Potassium ferricyanide played a dual role as a “CN” source and also as a coupling partner for the cyclization of oxazole.

中文翻译：

铜（II） -介导的形成从苯乙酮和协调的氰化物阴离子恶唑-4-甲腈通过一自由基偶合†

首先描述了由苯乙酮直接合成5-芳基恶唑-4-腈的方案，其中铁氰化钾是一种廉价且低毒性的氰化物试剂，其中通过氧介导的自由基机理实现了多键的形成。铁氰化钾起着“ CN”源的双重作用，同时也是恶唑环化的偶联伙伴。

更新日期：2017-05-05

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