Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge,Journal of Natural Products

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Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-04-28 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00121
Chang-Kwon Kim ₁ , Riswanto Riswanto ₁ , Tae Hyung Won ₁ , Heegyu Kim ₂ , Berna Elya ₃ , Chung J. Sim ₄ , Dong-Chan Oh ₁ , Ki-Bong Oh ₂ , Jongheon Shin ₁

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Five new manzamine alkaloids (1–5) and new salt forms of two known manzamines (6 and 7), along with seven known compounds (8–14) of the same structural class, were isolated from an Indonesian Acanthostrongylophora sp. sponge. On the basis of the results of combined spectroscopic analyses, the structure of kepulauamine A (1) was determined to possess an unprecedented pyrrolizine moiety, while others were functional group variants of known manzamines. These compounds exhibited weak cytotoxicity, moderate antibacterial activity, and mild inhibition against the enzyme isocitrate lyase.

中文翻译：

Acanthostrongylophora sp。的Manzamine生物碱。海绵

五个新manzamine生物碱（1 - 5）和新的盐形式的两种已知manzamines（6和7），用七种已知化合物（沿8 - 14）相同的结构类的，从一个印度尼西亚分离Acanthostrongylophora藻。海绵。基于组合光谱分析的结果，确定了kepulauamine A（1）的结构具有空前的吡咯烷嗪部分，而其他则是已知的manzamines的官能团变体。这些化合物显示出弱的细胞毒性，适度的抗菌活性以及对异柠檬酸裂合酶的温和抑制作用。

更新日期：2017-04-28

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