In an aim to expand the scope of aryne chemistry with new synthons, a domino aryne precursor bearing an additional ortho-OTf group on Kobayashi reagent is proposed and synthesized. 2,4-Disubstituted benzothiazole could be achieved from benzothioamide derivatives and this reagent with a sequential incorporation of C–S, C–N, and C–C bonds on the consecutive positions of the aryne precursor.

中文翻译：

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Domino Aryne Precursor：超越传统Aryne化学界限的一步

为了用新的合成子扩大芳炔化学的范围，提出并合成了一种在小林试剂上带有额外邻位 OTf 基团的多米诺芳炔前体。2,4-二取代的苯并噻唑可以从苯硫代酰胺衍生物和这种试剂中获得，在芳炔前体的连续位置上依次加入 C-S、C-N 和 C-C 键。