An approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines via the cyclization of 1-(2-(3-azidopropyl)pyridin-3-yl)alkanones under Staudinger–aza-Wittig reaction conditions is described. The overall reaction sequence includes eight steps and allows for the preparation of gram quantities of the title products. In some cases, the formation of 5,7,8,9-tetrahydrooxepino[4,3-b]pyridine derivatives was observed.

中文翻译：

---

5-取代的6,7,8,9-四氢-5H-吡啶并[3,2-c] a庚烷的制备方法

通过在Staudinger下将1-（2-（3-叠氮基丙基）吡啶-3-基）烷酮环化来制备5-取代的6,7,8,9-四氢-5H-吡啶并[3,2-c]氮杂ze的方法描述了–aza-Wittig反应条件。整个反应过程包括八个步骤，可以制备克量的标题产物。在某些情况下，观察到了5,7,8,9-四氢氧哌啶[4,3-b]吡啶衍生物的形成。