The report presents a first example of a regio- and stereospecific Lewis acid-catalyzed aminolysis of 1-benzyl-3,4-epoxypiperidine leading to trans-3-amino-1-benzylpiperidin-4-ols, in contrast with other Lewis acid-catalyzed reactions leading to trans-4-amino-1-benzylpiperidin-3-ols. The reaction is performed at room temperature using the reagents prepared by interaction of a hard Lewis acid – diisobutylaluminum hydride (DIBAL-H) with primary and secondary amines. The obtained products are potential intermediates on the way to stereochemical analogues of the antitumor piperidine alkaloid pseudodistomin D.

中文翻译：

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使用1-二甲基-3,4-环氧哌啶与二异丁基铝酰胺（DIBAL-NR ¹ R ²）的区域特异性裂解，可方便地合成反式-3-氨基-1-苄基哌啶-4-醇

该报告提供了第一个例子，与其他路易斯酸-相比，区域和立体特异性路易斯酸催化1-苄基-3,4-环氧哌啶的氨解导致反式-3-氨基-1-苄基哌啶-4-醇的氨解。催化反应，导致反式-4-氨基-1-苄基哌啶-3-醇。反应是在室温下使用由硬路易斯酸–二异丁基氢化铝（DIBAL-H）与伯胺和仲胺相互作用制得的试剂进行的。所获得的产物是抗肿瘤哌啶生物碱假distomin D的立体化学类似物上的潜在中间体。