A highly enantioselective 1, 3-dipolar cycloaddition of nitrone with α, β-unsaturated acyl phosphonate was developed for the first time by using a chiral indane-bis(oxazoline)-copper(II) complex. The reaction proceeded smoothly under mild conditions to provide isoxazolidines with multi-stereocenters in good yields with high to excellent diastereo- (>20:1 dr) and enantioselectivities (up to 99% ee). The resulting products were readily converted to multi-functional isoxazolidines or γ-amino alcohol compounds.

中文翻译：

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Cu（II）催化的硝基化合物与α，β-不饱和酰基膦酸酯的对映选择性1,3-偶极环加成

通过使用手性茚满-双（恶唑啉）-铜（II）配合物，首次开发了具有α，β-不饱和酰基膦酸酯的高对映选择性的1，3-偶极环硝基加成环。反应在温和条件下平稳进行，以高产率提供具有高至优异的非对映体-（＞ 20∶1dr）和对映选择性（高达99％ee）的具有多个立体中心的异恶唑烷。所得产物易于转化为多功能异恶唑烷或γ-氨基醇化合物。