Radical Borylation/Cyclization Cascade of 1,6-Enynes for the Synthesis of Boron-Handled Hetero- and Carbocycles,Journal of the American Chemical Society

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Radical Borylation/Cyclization Cascade of 1,6-Enynes for the Synthesis of Boron-Handled Hetero- and Carbocycles
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-04-19 , DOI: 10.1021/jacs.7b01889
Shi-Chao Ren ₁ , Feng-Lian Zhang ₁ , Jing Qi ₁ , Yun-Shuai Huang ₁ , Ai-Qing Xu ₁ , Hong-Yi Yan ₁ , Yi-Feng Wang ₁

Affiliation

A synthetic method to construct boron-handled cyclic molecules was developed based on a radical borylation/cyclization cascade of 1,6-enynes. The process was initiated by the chemo- and regio-controlled addition of an N-heterocyclic carbene-boryl radical to an alkene or alkyne, followed by ring closure to afford boron-substituted cyclic skeletons. Further molecular transformations of the cyclic products to synthetically useful building blocks were also demonstrated.

中文翻译：

用于合成硼处理的杂环和碳环的 1,6-烯炔的自由基硼酸化/环化级联

基于 1,6-烯炔的自由基硼化/环化级联，开发了一种构建硼处理环状分子的合成方法。该过程由化学和区域控制的 N-杂环卡宾硼基与烯烃或炔烃的加成开始，然后闭环以提供硼取代的环状骨架。还证明了环状产物向合成有用的结构单元的进一步分子转化。

更新日期：2017-04-19

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