Ophiobolin A [1], 3-anhydroophiobolin A [2], ophiobolin B [3], and ophiobolin L [4] were isolated from fermentation broths of Cochliobolus heterostrophus. Preliminary screening showed that a number of organisms were capable of metabolizing the sesterterpene ophiobolin A [1]. Large-scale transformations of ophiobolin A [1] with Polyangium cellulosum produced 6 and 7 while Pseudomonas aeruginosa produced 8. Resting-cell preparations of Penicillium patulum afforded 9 and 10. The structures of these metabolites were established by spectroscopic methods and by comparison of the spectral data with those of the starting material. The antimicrobial activity of the ophiobolins was also evaluated.

中文翻译：

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ophiobolin A的微生物代谢产物和ophiobolins的抗菌评估。

从异曲霉的发酵肉汤中分离出蛇胆碱A [1]，3-脱水蛇毒蛋白A [2]，蛇毒蛋白B [3]和蛇毒蛋白L [4]。初步筛选显示，许多生物体都能够代谢倍半萜烯麦芽糖醇A [1]。透明质酸A的大规模转化转化为ophiobolin A [1]产生了6和7，而铜绿假单胞菌产生了8和8。静息细胞制备的青霉菌提供了9和10。这些代谢物的结构是通过光谱法和通过比较得到的。光谱数据与起始材料的光谱数据相同。还评估了蛇麻素的抗菌活性。