The preparation of a range of 1,5-disubstituted tetrazoles has been achieved through palladium-catalyzed Suzuki coupling. Using appropriately substituted 5-p-toluenesulfonyltetrazoles as substrates (obtained by cycloaddition of a substituted azide with p-toluenesulfonyl cyanide), this methodology provides access to a variety of highly substituted tetrazoles that would be difficult to access otherwise. The procedure is compatible with functional groups commonly found in drug-like molecules, and has been used to generate a number of compounds of potential biological interest.

中文翻译：

---

通过钯催化的Suzuki偶联制备高度官能化的1,5-二取代的四唑

通过钯催化的Suzuki偶联已经实现了一系列1，5-二取代的四唑的制备。使用适当取代的5-对甲苯磺酰基四唑作为底物（通过将取代的叠氮化物与对甲苯磺酰基氰基环加成而获得），该方法提供了多种否则难以获得的高度取代的四唑的访问。该方法与通常在药物样分子中发现的官能团兼容，并已用于产生许多具有潜在生物学意义的化合物。