碳纳米管纤维微电极用于神经递质检测的评估：电化学性能和表面性质的相关性,Analytica Chimica Acta

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碳纳米管纤维微电极用于神经递质检测的评估：电化学性能和表面性质的相关性
Analytica Chimica Acta ( IF 5.7 ) Pub Date : 2017-03-31 09:39:06
Cheng Yang, Elefterios Trikantzopoulos, Christopher B. Jacobs, B. Jill Venton

由CNT制成的纤维是有吸引力的微电极传感器，因为它们可以直接制成微电极。已经开发出用于制造CNT纤维的不同方案，但是尚未研究表面结构的差异以及因此导致的电化学性质。在这项研究中，我们将三种类型的材料的神经化学检测的表面性质和电化学性质相关联：通过湿纺与（1）聚乙烯亚胺（PEI / CNT）或（2）氯磺酸（CA / CNT）和（ 3）通过基于固体的CNT拉伸制成的CNT纱线。CNT纱线具有良好排列的高纯度CNT，丰富的氧官能团和适度的表面粗糙度，从而导致最高的多巴胺电流密度（290±65 pA / cm ^2））和最快的电子转移动力学。CNT纱线和PEI / CNT纤维微电极的缝隙使多巴胺在快速扫描循环伏安法检测过程中瞬间被捕获，从而导致薄层电池状况以及与施加的波形频率无关的响应。PEI / CNT纤维上较大的缝隙导致较慢的时间响应，显示出太多的粗糙度不利于快速检测。CA / CNT纤维的表面较光滑，电流较低，但它们的负电荷使多巴胺对尿酸或抗坏血酸的选择性较高。总体而言，小缝隙，高电导率和丰富的氧基团导致对胺类神经递质（如多巴胺和5-羟色胺）的高敏感性。因此，

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Evaluation of carbon nanotube fiber microelectrodes for neurotransmitter detection: Correlation of electrochemical performance and surface properties

Fibers made of CNTs are attractive microelectrode sensors because they can be directly fabricated into microelectrodes. Different protocols for making CNT fibers have been developed, but differences in surface structure and therefore electrochemical properties that result have not been studied. In this study, we correlated the surface and electrochemical properties for neurochemical detection at 3 types of materials: CNT fibers produced by wet spinning with (1) polyethylenimine (PEI/CNT) or (2) chlorosulfonic acid (CA/CNT), and (3) CNT yarns made by solid-based CNT drawing. CNT yarns had well-aligned, high purity CNTs, abundant oxygen functional groups, and moderate surface roughness which led to the highest dopamine current density (290 ± 65 pA/cm²) and fastest electron transfer kinetics. The crevices of the CNT yarn and PEI/CNT fiber microelectrodes allow dopamine to be momentarily trapped during fast-scan cyclic voltammetry detection, leading to thin-layer cell conditions and a response that was independent of applied waveform frequency. The larger crevices on the PEI/CNT fibers led to a slower time response, showing too much roughness is detrimental to fast detection. CA/CNT fibers have a smoother surface and lower currents, but their negative surface charge results in high selectivity for dopamine over uric acid or ascorbic acid. Overall, small crevices, high conductivity, and abundant oxygen groups led to high sensitivity for amine neurotransmitters, such as dopamine and serotonin. Thus, different surfaces of CNT fibers result in altered electrochemical properties and could be used in the future to predict and control electrochemical performance.

更新日期：2017-04-01

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