Metal–Organic Framework (MOF)-Based Drug/Cargo Delivery and Cancer Therapy,Advanced Materials

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Metal–Organic Framework (MOF)-Based Drug/Cargo Delivery and Cancer Therapy
Advanced Materials ( IF 27.4 ) Pub Date : 2017-03-29 06:46:13 , DOI: 10.1002/adma.201606134
Ming-Xue Wu ₁ , Ying-Wei Yang ₁

Affiliation

Metal–organic frameworks (MOFs)—an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers—have attracted increasing attention in recent years. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, make them promising candidates as drug delivery hosts. Furthermore, scientists have made remarkable achievements in the field of nanomedical applications of MOFs, owing to their facile synthesis on the nanoscale and alternative functionalization via inclusion and surface chemistry. A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.

中文翻译：

基于金属有机框架（MOF）的药物/货物递送和癌症治疗

近年来，金属有机框架（MOF）是一类新兴的混合多孔材料，由金属离子或由有机连接基桥接的簇构建而成。MOF的卓越性能，例如定义明确的孔径，可调整的组成和结构，可调节的尺寸，多功能的功能，高的载药量以及改善的生物相容性，使其成为有希望成为药物输送宿主的候选药物。此外，由于MOFs的纳米级合成简便，以及通过包含物和表面化学的替代功能化，因此在MOFs的纳米医学应用领域取得了令人瞩目的成就。此处简要介绍了近年来已报道的MOF在受控药物/货物递送和癌症治疗中的应用。

更新日期：2017-03-30

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