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Construction of blood compatible lysine-immobilized chitin/carbon nanotube microspheres and potential applications for blood purified therapy.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-04-05 , DOI: 10.1039/c7tb00101k Shuangquan Wu 1 , Bo Duan , Xianpeng Zeng , Ang Lu , Xiaojuan Xu , Yanfeng Wang , Qifa Ye , Lina Zhang
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-04-05 , DOI: 10.1039/c7tb00101k Shuangquan Wu 1 , Bo Duan , Xianpeng Zeng , Ang Lu , Xiaojuan Xu , Yanfeng Wang , Qifa Ye , Lina Zhang
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Excess bilirubin often evokes hepatobiliary system dysfunction. In the present work, we developed an efficient, safe and blood compatible adsorbent for bilirubin removal from human blood. In view of the highly effective adsorption of carbon nanotubes (CNTs) on bilirubin but with many side effects, and good biocompatibility of chitin but with low efficiency for bilirubin removal, new chitin/carbon nanotube (Ch/CNT) nanofibrous microspheres were constructed from chitin solution in NaOH/urea aqueous system by blending with CNTs. The results of AFM, SEM, and TEM demonstrated that the CNTs were dispersed well in the chitin matrix, and the chitin nanofibers intertwined with CNTs to form hybrid chitin/CNT nanofibers and then weaved into a 3D interconnected network architecture. Moreover, lysine (Lys), a highly specific ligand for bilirubin, was immobilized tightly to the hybrid microspheres to obtain Ch/CNT/Lys. The resultant microspheres possessed large surface area and hierarchical pores including mesopores and micropores, which could allow bilirubin to enter easily and store, leading to highly efficient adsorption. The Ch/CNT/Lys microspheres exhibited excellent bilirubin adsorption property (107.2 mg g-1) and efficient bilirubin clearance rate from real hyperbilirubinemia plasma competing with protein, as well as good cell affinity and blood compatibility, as a result of the combination of the high adsorption of CNTs and inherent biocompatibility of chitin and lysine. Therefore, an effective strategy to develop a novel biocompatible and blood compatible bilirubin adsorbent is provided, showing potential applications for hemoperfusion in blood purified therapy.
中文翻译：
血液相容性赖氨酸固定的几丁质/碳纳米管微球的构建及其在血液净化治疗中的潜在应用。
胆红素过多常会引起肝胆系统功能障碍。在目前的工作中，我们开发了一种有效，安全且与血液相容的吸附剂，可从人血中去除胆红素。鉴于碳纳米管（CNTs）在胆红素上的高效吸附，但副作用很多，几丁质具有良好的生物相容性，但胆红素的去除效率低，因此，用几丁质构建了新的几丁质/碳纳米管（Ch / CNT）纳米纤维微球。通过与CNT混合在NaOH /脲水溶液系统中的溶液。AFM，SEM和TEM的结果表明，CNTs在几丁质基质中分散良好，几丁质纳米纤维与CNT缠绕在一起，形成杂化的几丁质/ CNT纳米纤维，然后编织成3D互连的网络体系结构。此外，赖氨酸（Lys）是胆红素的高度特异性配体，将其紧密固定在杂化微球上以获得Ch / CNT / Lys。所得的微球具有大的表面积和包括中孔和微孔在内的分层孔，这可以使胆红素容易进入并储存，从而导致高效吸附。Ch / CNT / Lys微球表现出优异的胆红素吸附性能（107.2 mg g-1），并与蛋白质竞争，从真正的高胆红素血症血浆中有效地清除了胆红素，并具有良好的细胞亲和力和血液相容性，碳纳米管的高吸附性以及几丁质和赖氨酸固有的生物相容性。因此，提供了开发新的生物相容性和血液相容性胆红素吸附剂的有效策略，显示了血液净化治疗中血液灌流的潜在应用。
更新日期：2017-03-22
中文翻译：
血液相容性赖氨酸固定的几丁质/碳纳米管微球的构建及其在血液净化治疗中的潜在应用。
胆红素过多常会引起肝胆系统功能障碍。在目前的工作中，我们开发了一种有效，安全且与血液相容的吸附剂，可从人血中去除胆红素。鉴于碳纳米管（CNTs）在胆红素上的高效吸附，但副作用很多，几丁质具有良好的生物相容性，但胆红素的去除效率低，因此，用几丁质构建了新的几丁质/碳纳米管（Ch / CNT）纳米纤维微球。通过与CNT混合在NaOH /脲水溶液系统中的溶液。AFM，SEM和TEM的结果表明，CNTs在几丁质基质中分散良好，几丁质纳米纤维与CNT缠绕在一起，形成杂化的几丁质/ CNT纳米纤维，然后编织成3D互连的网络体系结构。此外，赖氨酸（Lys）是胆红素的高度特异性配体，将其紧密固定在杂化微球上以获得Ch / CNT / Lys。所得的微球具有大的表面积和包括中孔和微孔在内的分层孔，这可以使胆红素容易进入并储存，从而导致高效吸附。Ch / CNT / Lys微球表现出优异的胆红素吸附性能（107.2 mg g-1），并与蛋白质竞争，从真正的高胆红素血症血浆中有效地清除了胆红素，并具有良好的细胞亲和力和血液相容性，碳纳米管的高吸附性以及几丁质和赖氨酸固有的生物相容性。因此，提供了开发新的生物相容性和血液相容性胆红素吸附剂的有效策略，显示了血液净化治疗中血液灌流的潜在应用。
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