Fluorescent bioimaging of pH: from design to applications,Chemical Society Reviews

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Fluorescent bioimaging of pH: from design to applications
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-03-20 00:00:00 , DOI: 10.1039/c6cs00719h
Ji-Ting Hou _{1,

2,

3,

4} , Wen Xiu Ren _{1,

2,

3,

4} , Kun Li _{5,

6,

7,

8} , Jinho Seo _{1,

2,

3,

4} , Amit Sharma _{1,

2,

3,

4} , Xiao-Qi Yu _{5,

6,

7,

8} , Jong Seung Kim _{1,

2,

3,

4}

Affiliation

Protons play crucial roles in many physiological and pathological processes, such as receptor-mediated signal transduction, ion transport, endocytosis, homeostasis, cell proliferation, and apoptosis. The urgent demand for pH imaging and measurement in biological systems has incited the development of fluorescent pH probes. Numerous fluorescent probes have been reported, but many lack the abilities needed for biological applications. Hence, the development of new pH probes with better biocompatibility, sensitivity, and site-specificity is still indispensable. This review highlights the recent trends in the development of fluorescent materials as essential tools for tracing pH variations in the biological processes of diverse living systems.

中文翻译：

pH的荧光生物成像：从设计到应用

质子在许多生理和病理过程中起着至关重要的作用，例如受体介导的信号转导，离子转运，内吞作用，体内平衡，细胞增殖和凋亡。在生物系统中对pH成像和测量的迫切需求激发了荧光pH探针的发展。已经报道了许多荧光探针，但是许多荧光探针缺乏生物学应用所需的能力。因此，开发具有更好的生物相容性，敏感性和位点特异性的新型pH探针仍然是必不可少的。这篇综述强调了荧光材料发展的最新趋势，荧光材料已成为追踪各种生命系统生物过程中pH值变化的基本工具。

更新日期：2017-03-20

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