Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice [Physiology],Proceedings of the National Academy of Sciences of the United States of America

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Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice [Physiology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2017-03-07 10:49:26 , DOI: 10.1073/pnas.1621069114
Haruka Okamoto ₁ , Katie Cavino ₁ , Erqian Na ₁ , Elizabeth Krumm ₁ , Sun Y. Kim ₁ , Xiping Cheng ₁ , Andrew J. Murphy ₁ , George D. Yancopoulos ₁ , Jesper Gromada ₁

Affiliation

Inactivating mutations in the insulin receptor results in extreme insulin resistance. The resulting hyperglycemia is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes. We used the insulin receptor antagonist S961 to induce severe insulin resistance, hyperglycemia, and ketonemia in mice....

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