脑肿瘤的术前检测和术中可视化以实现更精确的手术：新型双模态MRI和NIR纳米探针,Small

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脑肿瘤的术前检测和术中可视化以实现更精确的手术：新型双模态MRI和NIR纳米探针
Small ( IF 13.0 ) Pub Date : 2015-06-08 , DOI: 10.1002/smll.201500997
Chunyan Li ₁ , Limin Cao ₁ , Yejun Zhang ₁ , Peiwei Yi ₁ , Mao Wang ₁ , Bo Tan ₁ , Zongwu Deng ₁ , Dongmin Wu ₁ , Qiangbin Wang ₁

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在临床实践中，由于其固有的浸润特性，很难在脑外科手术中确定肿瘤边缘。本文报道了一种独特的双峰纳米探针（Gd-DOTA-Ag ₂ S量子点，称为Gd-Ag ₂ S纳米探针），其结合了增强的Gd磁共振（MR）成像的深层组织穿透优势和Ag ₂的第二个近红外窗口（NIR-II）中荧光成像的高信噪比和高时空分辨率S个量子点（QD）。由于丰富的肿瘤血管生成以及在肿瘤中增强的通透性和保留效果，借助Gd辅助的T1 MR成像可以清晰地原位描述小鼠模型中的脑肿瘤（U87MG），并且可以在术中切除肿瘤在静脉注射Gd-Ag ₂ S纳米探针后，在Ag ₂ S QD的NIR-II荧光成像的指导下精确完成。此外，施用Gd-Ag ₂ S纳米探针1个月后，小鼠主要器官未观察到组织学变化，表明该纳米探针具有很高的生物相容性。我们期望基于Gd-Ag _2的这种新颖的“检测与操作”策略S纳米探针在未来的临床应用中很有前途。

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Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual‐Modality MRI and NIR Nanoprobe

In clinical practice, it is difficult to identify tumor margins during brain surgery due to its inherent infiltrative character. Herein, a unique dual‐modality nanoprobe (Gd‐DOTA‐Ag₂S QDs, referred as Gd‐Ag₂S nanoprobe) is reported, which integrates advantages of the deep tissue penetration of enhanced magnetic resonance (MR) imaging of Gd and the high signal‐to‐noise ratio and high spatiotemporal resolution of fluorescence imaging in the second near‐infrared window (NIR‐II) of Ag₂S quantum dots (QDs). Due to the abundant tumor angiogenesis and the enhanced permeability and retention effect in the tumor, a brain tumor (U87MG) in a mouse model is clearly delineated in situ with the help of the Gd assisted T1 MR imaging and the intraoperative resection of the tumor is precisely accomplished under the guidance of NIR‐II fluorescence imaging of Ag₂S QDs after intravenous injection of Gd‐Ag₂S nanoprobe. Additionally, no histologic changes are observed in the main organs of the mouse after administration of Gd‐Ag₂S nanoprobe for 1 month, indicating the high biocompatibility of the nanoprobe. We expect that such a novel “Detection and Operation” strategy based on Gd‐Ag₂S nanoprobe is promising in future clinical applications.

更新日期：2015-06-08

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