An environmentally benign alkylation of barbituric acids via “borrowing hydrogen” process with ruthenium catalysis has been established. The corresponding 5-(alkyl)barubituric acids were obtained in good to excellent yields with low catalyst loading. Various substrates including aliphatic alcohols were tolerated in the present catalytic system. A novel method for construction of barbituric acid-fused benzopyrane derivatives was also demonstrated.

中文翻译：

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通过“借用氢”方法，钌催化选择性合成单烷基化的巴比妥酸

已经建立了通过“借入氢”过程和钌催化对巴比妥酸进行无害环境的烷基化反应。以低催化剂负载量以良好至优异的产率获得了相应的5-（烷基）Barubituric酸。在本催化体系中，包括脂肪族醇在内的各种底物是可容许的。还证明了一种新的构建巴比妥酸稠合的苯并吡喃衍生物的方法。