ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection [Microbiology],Proceedings of the National Academy of Sciences of the United States of America

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ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection [Microbiology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2017-02-21 12:11:35 , DOI: 10.1073/pnas.1614268114
Anna Vysochan _{1,

2} , Arjun Sengupta _{3,

4} , Aalim M. Weljie _{3,

4} , James C. Alwine _{1,

2} , Yongjun Yu _{1,

2}

Affiliation

Recent studies have shown that human cytomegalovirus (HCMV) can induce a robust increase in lipid synthesis which is critical for the success of infection. In mammalian cells the central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate or by acetyl-CoA synthetase...

中文翻译：

由乙酸盐合成的ACSS2介导的乙酰辅酶A对人类巨细胞病毒感染是必需的[微生物学]

最近的研究表明，人类巨细胞病毒（HCMV）可以诱导脂质合成的强劲增长，这对于感染的成功至关重要。在哺乳动物细胞中，脂质生物合成的主要前体细胞质乙酰辅酶A（Ac-CoA）是由线粒体来源的柠檬酸的ATP柠檬酸裂解酶（ACLY）或乙酰辅酶A合成酶产生的。

更新日期：2017-02-24

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