Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein [Biophysics and Computational Biology],Proceedings of the National Academy of Sciences of the United States of America

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Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein [Biophysics and Computational Biology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2017-02-14 10:09:14 , DOI: 10.1073/pnas.1616783114
Kinlin L Chao ₁ , Liudmila Kulakova ₁ , Osnat Herzberg _{2,

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Affiliation

The exact function of human gasdermin-B (GSDMB), which regulates differentiation and growth of epithelial cells, is yet to be elucidated. In human epidermal growth factor receptor 2 (HER2)-positive breast cancer, GSDMB gene amplification and protein overexpression indicate a poor response to HER2-targeted therapy. Genome-wide association studies revealed a correlation between...

中文翻译：

与哮喘和 IBD 风险增加相关的基因多态性改变了gasdermin-B结构，这是一种硫苷脂和磷酸肌醇结合蛋白[生物物理学和计算生物学]

人 Gasdermin-B (GSDMB) 调节上皮细胞分化和生长的确切功能尚未阐明。在人表皮生长因子受体 2 (HER2) 阳性乳腺癌中，GSDMB 基因扩增和蛋白过度表达表明对 HER2 靶向治疗的反应较差。全基因组关联研究揭示了……之间的相关性

更新日期：2017-02-17

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