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Supramolecular “Trojan Horse” for Nuclear Delivery of Dual Anticancer Drugs
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-02-14 , DOI: 10.1021/jacs.6b12322 Yanbin Cai 1 , Haosheng Shen 1 , Jie Zhan 1 , Mingliang Lin 1 , Liuhan Dai 1 , Chunhua Ren 2 , Yang Shi 1 , Jianfeng Liu 2 , Jie Gao 1 , Zhimou Yang 1
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-02-14 , DOI: 10.1021/jacs.6b12322 Yanbin Cai 1 , Haosheng Shen 1 , Jie Zhan 1 , Mingliang Lin 1 , Liuhan Dai 1 , Chunhua Ren 2 , Yang Shi 1 , Jianfeng Liu 2 , Jie Gao 1 , Zhimou Yang 1
Affiliation
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Nuclear delivery and accumulation are very important for many anticancer drugs that interact with DNA or its associated enzymes in the nucleus. However, it is very difficult for neutrally and negatively charged anticancer drugs such as 10-hydroxycamptothecine (HCPT). Here we report a simple strategy to construct supramolecular nanomedicines for nuclear delivery of dual synergistic anticancer drugs. Our strategy utilizes the coassembly of a negatively charged HCPT-peptide amphiphile and the positively charged cisplatin. The resulting nanomaterials behave as the "Trojan Horse" that transported soldiers (anticancer drugs) across the walls of the castle (cell and nucleus membranes). Therefore, they show improved inhibition capacity to cancer cells including the drug resistant cancer cell and promote the synergistic tumor suppression property in vivo. We envision that our strategy of constructing nanomaterials by metal chelation would offer new opportunities to develop nanomedicines for combination chemotherapy.
中文翻译：
用于双重抗癌药物核递送的超分子“特洛伊木马”
核传递和积累对于许多与核中 DNA 或其相关酶相互作用的抗癌药物非常重要。然而，中性和带负电荷的抗癌药物如 10-羟基喜树碱 (HCPT) 很难获得。在这里，我们报告了一种构建超分子纳米药物的简单策略，用于双协同抗癌药物的核递送。我们的策略利用带负电荷的 HCPT 肽两亲物和带正电荷的顺铂的共组装。由此产生的纳米材料就像“特洛伊木马”一样，将士兵（抗癌药物）运送到城堡的墙壁（细胞和细胞核膜）。所以，它们对包括耐药性癌细胞在内的癌细胞显示出改善的抑制能力，并在体内促进了协同肿瘤抑制特性。我们设想我们通过金属螯合构建纳米材料的策略将为开发用于联合化疗的纳米药物提供新的机会。
更新日期：2017-02-14
中文翻译：
用于双重抗癌药物核递送的超分子“特洛伊木马”
核传递和积累对于许多与核中 DNA 或其相关酶相互作用的抗癌药物非常重要。然而，中性和带负电荷的抗癌药物如 10-羟基喜树碱 (HCPT) 很难获得。在这里，我们报告了一种构建超分子纳米药物的简单策略，用于双协同抗癌药物的核递送。我们的策略利用带负电荷的 HCPT 肽两亲物和带正电荷的顺铂的共组装。由此产生的纳米材料就像“特洛伊木马”一样，将士兵（抗癌药物）运送到城堡的墙壁（细胞和细胞核膜）。所以，它们对包括耐药性癌细胞在内的癌细胞显示出改善的抑制能力，并在体内促进了协同肿瘤抑制特性。我们设想我们通过金属螯合构建纳米材料的策略将为开发用于联合化疗的纳米药物提供新的机会。
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