A convenient synthesis of substituted spiroindenoquinoxalines at mild and green conditions was developed. Multicomponent reaction of substituted phenylene diamines, ninhydrin, malononitrile and N,N’-substituted-2-nitroethene-1,1-diamines produced the target compounds. Twelve new spiroindenoquinoxalines were obtained, and their ability in inhibition of acetyl and butyrylcholinesterases were investigated both in-vitro and in-silico. All compounds showed moderate level activity against both acetyl and butyrylcholinesterases.

中文翻译：

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新型螺-茚并喹喔啉衍生物的绿色合成及其对胆碱酯酶的抑制活性

开发了一种在温和绿色条件下方便合成取代螺螺旋茚并喹喔啉的方法。取代的苯二胺，茚三酮，丙二腈和N，N'-取代的-2-硝基乙烯-1,1-二胺的多组分反应制得目标化合物。获得了十二种新的螺萘醌喹喔啉，并在体外和计算机模拟中研究了它们抑制乙酰基和丁酰胆碱酯酶的能力。所有化合物对乙酰基和丁酰胆碱酯酶均显示中等水平的活性。