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Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene.
Chemical Communications ( IF 4.3 ) Pub Date : 2015 Feb 21 , DOI: 10.1039/c4cc09655j Navanita T. Thirumoorthi 1, 2, 3, 4, 5 , Chew Jia Shen 1, 2, 3, 4, 5 , Vikrant A. Adsool 1, 2, 3, 4, 5
Chemical Communications ( IF 4.3 ) Pub Date : 2015 Feb 21 , DOI: 10.1039/c4cc09655j Navanita T. Thirumoorthi 1, 2, 3, 4, 5 , Chew Jia Shen 1, 2, 3, 4, 5 , Vikrant A. Adsool 1, 2, 3, 4, 5
Affiliation
Recently, the potential utility of the BCP motif, as a contemporary lead optimization tactic, has generated substantial interest in medicinal chemistry. To facilitate this inquisitiveness, the concomitant development of efficient synthetic protocols is crucial. The following work discloses a new, expedient and versatile approach to one such potentially useful BCP derivative.
中文翻译:
通过苯的无金属均相芳族烷基化合成3-苯基双环[1.1.1]戊丹-1-胺。
最近,作为当代领先的优化策略,BCP主题的潜在用途已引起人们对药物化学的浓厚兴趣。为了促进这种好奇心,随之而来的是开发有效的合成方案至关重要。以下工作公开了一种新的,便捷且通用的方法来处理这种潜在有用的BCP衍生物。
更新日期:2017-01-31
中文翻译:
通过苯的无金属均相芳族烷基化合成3-苯基双环[1.1.1]戊丹-1-胺。
最近,作为当代领先的优化策略,BCP主题的潜在用途已引起人们对药物化学的浓厚兴趣。为了促进这种好奇心,随之而来的是开发有效的合成方案至关重要。以下工作公开了一种新的,便捷且通用的方法来处理这种潜在有用的BCP衍生物。