Department of Biomedical Engineering; Case Western Reserve University; Cleveland OH 44106 USA
Department of Orthopaedic Surgery; Case Western Reserve University; Cleveland OH 44106 USA
E. Alsberg及其同事证明了室温下在宽pH范围内简单地将可光交联的甲基丙烯酸藻酸盐和甲基丙烯酸明胶简单混合而成的凝聚层微滴和/或凝聚有光交联水凝胶的自发形成。第2216页。该系统可用作将平台化的，持续的生物活性分子原位形成到封装的干细胞中以进行治疗的原位形成新平台。
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Hydrogels: In‐Situ Formation of Growth‐Factor‐Loaded Coacervate Microparticle‐Embedded Hydrogels for Directing Encapsulated Stem Cell Fate (Adv. Mater. 13/2015)
E. Alsberg and co‐workers demonstrate the spontaneous formation of coacervate microdroplets and/or coacervate‐laden photo‐crosslinked hydrogels derived from the simple mixing of photo‐crosslinkable methacrylated alginate and methacrylated gelatin over a wide pH range at room temperature, as described on page 2216. This system can be utilized as a novel platform for in situ formation of localized, sustained bioactive molecule delivery to encapsulated stem cells for therapeutic applications.
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