The structural preciseness of dendrimers makes them perfect drug delivery carriers, particularly in the form of dendrimer–drug conjugates. Current dendrimer–drug conjugates are synthesized by anchoring drug and functional moieties onto the dendrimer peripheral surface. However, functional groups exhibiting the same reactivity make it impossible to precisely control the number and the position of the functional groups and drug molecules anchored to the dendrimer surface. This structural heterogeneity causes variable pharmacokinetics, preventing such conjugates to be translational. Furthermore, the highly hydrophobic drug molecules anchored on the dendrimer periphery can interact with blood components and alter the pharmacokinetic behavior. To address these problems, we herein report molecularly precise dendrimer–drug conjugates with drug moieties buried inside the dendrimers. Surprisingly, the drug release rates of these conjugates were tailorable by the dendrimer generation, surface chemistry, and acidity.

中文翻译：

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分子精确的树状聚合物与药物结合可调节的药物释放，可用于癌症治疗。

树枝状大分子的结构精确度使其成为理想的药物输送载体，尤其是树枝状大分子-药物结合物的形式。当前的树状聚合物-药物缀合物是通过将药物和功能部分锚定在树状聚合物的外周表面上而合成的。然而，表现出相同反应性的官能团使得不可能精确控制锚定在树枝状聚合物表面上的官能团和药物分子的数量和位置。这种结构上的异质性导致可变的药代动力学，从而阻止了这种缀合物的翻译。此外，锚定在树枝状聚合物外围的高度疏水的药物分子可与血液成分相互作用并改变药代动力学行为。为了解决这些问题，我们在这里报道了分子精确的树状聚合物-药物缀合物，其中药物部分掩埋在树状聚合物中。出人意料的是，这些缀合物的药物释放速率可通过树枝状聚合物的产生，表面化学性质和酸度来调节。