A novel total synthesis of aculeatin A via a stepwise approach†,RSC Advances

当前位置： X-MOL 学术 › RSC Adv. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A novel total synthesis of aculeatin A via a stepwise approach†
RSC Advances ( IF 3.9 ) Pub Date : 2017-02-02 00:00:00 , DOI: 10.1039/c6ra27140e
Zhibin Zhang _{1,

2,

3,

4} , Xiao Leng _{2,

3,

4,

5} , Shenkun Yang _{1,

2,

3,

4} , Cheng Liang _{1,

2,

3,

4} , Shuangping Huang _{1,

2,

3,

4} , Xiaoji Wang _{2,

3,

4,

6}

Affiliation

Aculeatin A, isolated from the plant Amomum aculeatum, is a dispirocyclic compound having antimalarial activity. In this paper, we describe a novel synthetic approach to aculeatin A from 1-tetradecanal in nine steps via a stepwise strategy. The key features of this approach include the 1,3-diketone preparation from Claisen condensation of ketone and acyl chloride, cyclodehydration, and intramolecular oxa-Michael addition to 2,3-dihydro-4H-pyran-4-one.

中文翻译：

通过逐步的方法，新的aculeatin A的全合成†

从植物砂仁中分离出的Aculeatin A是一种具有抗疟疾活性的双螺环化合物。在本文中，我们通过一种逐步策略，描述了一种从九-步骤中从1-十四烷中合成aculeatin A的新颖方法。该方法的关键特征包括由Claisen的酮与酰氯的Claisen缩合制备1，3-二酮，进行环脱水作用，以及向2，3-dihydro-4 H -pyran-4-one中添加分子内的oxa-Michael 。

更新日期：2017-02-02

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南