Direct cross-coupling between simple arenes and heterocyclic amines under mild conditions is undoubtedly important for C-N bonds construction. Selective C(sp²)-H amination is more valuable. Herein we show a selective C(sp²)-H amination of arenes (alkyl-substituted benzenes, biphenyl and anisole derivatives) accompanied by hydrogen evolution by using heterocyclic azoles as nitrogen sources. The reaction is selective for C(sp²)-H bonds, providing a mild route to N-arylazoles. The KIE (kinetic isotope effect) experiment reveals the cleavage of C-H bond is not involved in the rate-determining step. Kinetic studies indicate the first-order behaviour with respect to the arene component. It is interesting that this system works without the need for any sacrificial oxidant and is highly selective for C(sp²)-H activation, whereas C(sp³)-H bonds are unaffected. This study may have significant implications for the functionalization of methylarenes which are sensitive to oxidative conditions.

中文翻译：

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芳烃和唑之间的光诱导无氧化剂氧化CH / NH交叉偶联。

在温和条件下，简单的芳烃与杂环胺之间的直接交叉偶联无疑对CN键的构建很重要。选择性C（sp ²）-H胺化更有价值。本文中，我们显示了使用杂环唑类作为氮源时，芳烃（烷基取代的苯，联苯和苯甲醚衍生物）的选择性C（sp ²）-H胺化反应，伴随着氢气的逸出。该反应对C（sp ²）-H键，提供了通向N-芳基唑的温和途径。KIE（动力学同位素效应）实验表明，速率确定步骤中不涉及CH键的裂解。动力学研究表明有关芳烃成分的一阶行为。有趣的是，该系统无需任何牺牲氧化剂即可工作，并且对C（sp ²）-H活化具有高度选择性，而C（sp ³）-H键不受影响。这项研究可能对对氧化条件敏感的甲基芳烃的功能化具有重要意义。