Core‐Structure‐Motivated Design of Iminium–Enolate Organocascade Reactions: Enantioselective Syntheses of 5,6‐Dihydroindolizines,Angewandte Chemie International Edition

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Core‐Structure‐Motivated Design of Iminium–Enolate Organocascade Reactions: Enantioselective Syntheses of 5,6‐Dihydroindolizines
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2013-07-10 , DOI: 10.1002/anie.201303300
Xianxing Jiang ₁ , Bin Tan ₁ , Carlos F. Barbas ₁

Affiliation

Indolizine skeletons: A highly efficient dual iminium–enolate generation/activation process is introduced as a new platform for the design of organocatalytic intermolecular domino reactions for the direct construction of 5,6‐dihydroindolizine derivatives. This process provides ready access to indolizine skeletons with high optically purity from simple starting materials (see picture).

中文翻译：

烯醇式有机胺-胆酸酯反应的核-结构-动力设计：5,6-二氢吲哚并咪唑的对映选择性合成

吲哚嗪骨架：引入了高效的亚硝酸亚氨酯-烯醇双酸酯生成/活化过程，作为设计用于直接构建5，6-二氢吲哚嗪衍生物的有机催化分子间多米诺反应的新平台。通过此过程，可以从简单的原材料中轻松获得高光学纯度的吲哚嗪骨架（请参见图片）。

更新日期：2013-07-10

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