N-(2-Chlorobenzyl)-substituted hydroxamate, readily produced by hydrolysis of ketoclomazone, was identified as an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase (DXS), with an IC50 value of 1.0 muM. The compound inhibited the growth of Haemophilus influenzae. A convenient spectroscopic method for assaying DXS using NADPH-lactate dehydrogenase (LDH) is also reported.

中文翻译：

---

抗菌N-（2-氯苄基）取代的异羟肟酸酯是1-脱氧-D-木酮糖5-磷酸合酶的抑制剂。

N-（2-氯苄基）-取代的异羟肟酸酯很容易通过酮康唑酮的水解而产生，被鉴定为1-脱氧-D-木酮糖5-磷酸合酶（DXS）的抑制剂，IC50值为1.0μM。该化合物抑制流感嗜血杆菌的生长。还报道了使用NADPH-乳酸脱氢酶（LDH）测定DXS的简便光谱方法。