评估骨科生物材料血管生成特性的血管生成测定法-综述,Advanced Healthcare Materials

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评估骨科生物材料血管生成特性的血管生成测定法-综述
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-01-30 , DOI: 10.1002/adhm.201600434
Wai Ching Liu ₁ , Shihui Chen _{1,

2} , Lizhen Zheng ₁ , Ling Qin _{1,

3}

Affiliation

在骨骼发育和骨折修复过程中，血管化是骨骼形成，重塑和再生的重要过程。血管化仍然是一个巨大的挑战，直接导致新再生骨骼的最终成功。在这篇综述中，详细描述了不同的血管生成测定法和骨缺损模型的优缺点，以研究感兴趣的材料的血运重建。与使用生长因子或药物分子二维进行的常规血管生成研究不同，需要特别考虑是否可以转换这些测定法来测试三维可植入设备。多年来，准确，可量化的体外，离体和体内测定已广泛证明可用于检查新血管的生长。这些方法可以有助于对材料的血管生成特性的基本了解，但是骨缺损模型对于理解血管生成与骨形成的级联作用仍然至关重要。最后，血管生成和成骨都是相互影响的复杂过程，选择进行哪种测定应充分解决临床相关性并反映出测试材料血运重建的反应顺序。

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Angiogenesis Assays for the Evaluation of Angiogenic Properties of Orthopaedic Biomaterials – A General Review

Vascularization is an essential process in bone formation, remodeling and regeneration during both bone development and fracture repair. Vascularization remains a big challenge directly leading to the final success of newly regenerated bone. In this review, the advantages and disadvantages of different angiogenesis assays and bone defect models are described in details for investigating revascularization of materials of interest. Unlike conventional angiogenesis study with growth factors or pharmaceutical molecules performed in two‐dimension, special considerations are taken into account whether these assays can be translated for testing three‐dimensional implantable devices. Over the years, accurate and quantifiable in vitro, ex vivo and in vivo assays have been extensively demonstrated to be useful in examining how new blood vessels grow. These methods can contribute to the fundamental understanding of angiogenic properties of the materials, but a bone defect model is still pivotal in order to understand the cascade actions of angiogenesis along with bone formation. Finally, angiogenesis and osteogenesis are both complex processes interacting with each other, the choice of which assay to be performed should adequately address the clinical relevance and reflect the sequence of responses of revascularization of the test materials.

更新日期：2017-01-30

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