Pepping up Michael: An asymmetric Michael addition of nitromethane to β‐disubstituted α,β‐unsaturated aldehydes was realized by a resin‐supported peptide catalyst. Whereas the use of a low‐molecular‐weight catalyst resulted in poor yields, the peptide effectively promoted the reaction in aqueous media with high enantioselectivity.

中文翻译：

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肽催化的硝基甲烷对β-双取代的α，β-不饱和醛的不对称迈克尔加成反应，构建全碳四元立体中心

破坏迈克尔：通过树脂负载的肽催化剂实现了硝基甲烷向β-二取代的α，β-不饱和醛中的不对称迈克尔加成反应。尽管使用低分子量催化剂会导致收率低下，但该肽有效地促进了在水介质中具有高对映选择性的反应。