当前位置: X-MOL 学术Angew. Chem. Int. Ed. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Asymmetric Total Synthesis of the Epoxykinamycin FL‐120 B′
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2011-08-30 , DOI: 10.1002/anie.201104504
Stephen S Scully 1 , John A Porco
Affiliation  

Turn up the heat: The synthesis of the title compound was achieved and a route to epoxide‐containing diazobenzofluorenes, which could potentially serve as monomers to the dimeric lomaiviticins, was established. Key steps to construct the FL‐120B′ core structure include Sharpless asymmetric epoxidation, Stille coupling, and intramolecular Friedel–Crafts acylation of atropisomeric carboxylic acids at elevated temperatures.
image


中文翻译:

环氧激酶 FL-120 B' 的不对称全合成

调高热量:合成了标题化合物,并建立了含有环氧化物的重氮苯并芴的路线,该路线可能用作二聚体洛麦替尼的单体。构建 FL-120B' 核心结构的关键步骤包括高温下阻转异构羧酸的 Sharpless 不对称环氧化、Stille 偶联和分子内 Friedel-Crafts 酰化。
图片
更新日期:2011-08-30
down
wechat
bug