Cs2CO3‐Catalyzed Aerobic Oxidative Cross‐Dehydrogenative Coupling of Thiols with Phosphonates and Arenes,Angewandte Chemie International Edition

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Cs2CO3‐Catalyzed Aerobic Oxidative Cross‐Dehydrogenative Coupling of Thiols with Phosphonates and Arenes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-01-23 , DOI: 10.1002/anie.201612190
Song Song ₁ , Yiqun Zhang ₁ , Adeli Yeerlan ₁ , Bencong Zhu ₁ , Jianzhong Liu ₁ , Ning Jiao _{1,

2}

Affiliation

An efficient Cs₂CO₃‐catalyzed oxidative coupling of thiols with phosphonates and arenes that uses molecular oxygen as the oxidant is described. These reactions provide not only a novel alkali metal salt catalyzed aerobic oxidation, but also an efficient approach to thiophosphates and sulfenylarenes, which are ubiquitously found in pharmaceuticals and pesticides. The reaction proceeds under simple and mild reaction conditions, tolerates a wide range of functional groups, and is applicable to the late‐stage synthesis and modification of bioactive molecules.

中文翻译：

Cs2CO3催化的硫醇与膦酸酯和芳烃的需氧氧化交叉脱氢偶联

描述了使用分子氧作为氧化剂的高效Cs ₂ CO ₃催化的硫醇与膦酸酯和芳烃的氧化偶联。这些反应不仅提供了一种新颖的碱金属盐催化的好氧氧化反应，而且提供了一种在制药和农药中普遍发现的硫代磷酸盐和亚硫基芳烃的有效方法。该反应在简单温和的反应条件下进行，可耐受各种官能团，适用于生物活性分子的后期合成和修饰。

更新日期：2017-01-23

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