Finding the best catalyst: A set of P450 BM3 variants was tested for stereoselective hydroxylation of benzoic acid derivatives, with the goal of synthesizing phthalides and isocoumarins. We obtained variants giving access to R‐ and S‐configured products constituting a new route to a class of compounds that are valuable synthons for a variety of natural products.

中文翻译：

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P450 BM3催化的区域和立体选择性羟化反应，旨在合成邻苯二甲酰亚胺和异香豆素

寻找最佳催化剂：测试了一组P450 BM3变体对苯甲酸衍生物的立体选择性羟基化的作用，目的是合成邻苯二甲酸酯和异香豆素。我们获得了可以访问R和S构型产品的变体，这些产品构成了通往一类化合物的新途径，这些化合物对于各种天然产物都是有价值的合成子。