Tunable Bromomagnesium Thiolate Tishchenko Reaction Catalysts: Intermolecular Aldehyde–Trifluoromethylketone Coupling,Angewandte Chemie International Edition

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Tunable Bromomagnesium Thiolate Tishchenko Reaction Catalysts: Intermolecular Aldehyde–Trifluoromethylketone Coupling
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2010-03-18 , DOI: 10.1002/anie.200907167
Linda Cronin ₁ , Francesco Manoni ₁ , Cornelius J. O' Connor ₁ , Stephen J. Connon ₁

Affiliation

Applied knowledge: A new thiolate‐catalyzed Tishchenko reaction inspired by biochemical processes features exceptionally good control over the catalyst's steric/electronic properties. The isolation of reaction intermediates provided valuable insights into the reaction mechanism, which in turn has allowed the development of the first cross‐Tishchenko coupling reactions between aldehydes and activated ketones (see example).

中文翻译：

可调谐的溴化镁硫氰酸盐Tishchenko反应催化剂：分子间醛-三氟甲基酮偶联

应用知识：受生化过程启发的硫醇盐催化的新的Tishchenko反应具有对催化剂的空间/电子性质的出色控制。反应中间体的分离为反应机理提供了有价值的见解，这反过来又使醛与活化酮之间的第一个交叉-蒂申科偶合反应得以发展（参见示例）。

更新日期：2010-03-18

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