Leaching in ammonium citrate has been extensively used to assess the fraction of water-soluble nickel compounds present in nickel producing and using workplace aerosols. Leaching in ammonium citrate according to the first step of the Zatka protocol was found to overestimate the water-soluble nickel fraction by more than ten-fold compared to synthetic lung fluid (37 degrees C), when nickel carbonate and subsulfide were present. These results suggest that exposure matrices based on this method should be reexamined. Leaching studies of refinery particles are needed to further clarify this important issue.

中文翻译：

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温度对柠檬酸铵中镍释放的影响。

柠檬酸铵中的浸出已被广泛用于评估在生产和使用工作场所气雾剂的镍中存在的水溶性镍化合物的比例。当存在碳酸镍和亚硫化物时，与合成的肺液（37摄氏度）相比，发现根据Zatka协议第一步的柠檬酸铵浸出高估了水溶性镍含量（比合成肺液（37摄氏度）高十倍）。这些结果表明应重新检查基于此方法的曝光矩阵。需要对精炼厂颗粒进行浸出研究，以进一步阐明这一重要问题。