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Front Cover Picture: Redox‐Neutral Arylations of Vinyl Cation Intermediates (Adv. Synth. Catal. 1/2017)
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-01-11 , DOI: 10.1002/adsc.201601440
Daniel Kaiser 1 , Luis F. Veiros 2 , Nuno Maulide 1
Affiliation  

The front cover image, provided by Giovanni Di Mauro, Daniel Kaiser and Nuno Maulide, illustrates the conversion of vinyl cations, as high‐energy intermediates, into systems prone to charge‐accelerated Claisen‐type [3,3]‐sigmatropic rearrangements. Starting from simple precursors, vinyl cation formation enables a rapid increase of molecular complexity, affording α‐arylated carbonyl compounds that can be easily elaborated into drug‐like scaffolds. The setting to this cascade of reactions is provided by the famous (and beautiful) Karlskirche in Vienna (Foto: G. Kücükkaplan). Further details can be found in the full paper on page 64–77 (D. Kaiser, L. F. Veiros, N. Maulide, Adv. Synth. Catal. 2017, 359, 64–77; DOI: 10.1002/adsc.201600860)
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中文翻译:

封面图片:乙烯基阳离子中间体的氧化还原中性芳基化(Adv。Synth。Catal.1 / 2017)

封面图片由Giovanni Di Mauro,Daniel Kaiser和Nuno Maulide提供,展示了乙烯基阳离子作为高能中间体的转化为易于电荷加速的Claisen型[3,3]-σ重排的系统。从简单的前体开始,乙烯基阳离子的形成使分子的复杂性迅速增加,提供了可以容易地制成药物样支架的α-芳基化羰基化合物。维也纳著名的(也是美丽的)卡尔斯基教堂提供了这种级联反应的设置(照片:G。Kücükkaplan)。进一步的细节可以在全文中找到64-77页上(D.凯泽,L. F. Veiros,N. Maulide,进阶合成器CATAL。 2017359,64-77; DOI:10.1002 / adsc.201600860)
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更新日期:2017-01-11
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